c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.

Anne-Laure Mahul-Mellier, Bruno Fauvet, Amanda Gysbers, Igor Dikiy, Abid Oueslati, Sandrine Georgeon, Allan J. Lamontanara, Alejandro Bisquertt, David Eliezer, Eliezer Masliah, Glenda Halliday, Oliver Hantschel, and Hilal A. Lashuel. c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. Hum Mol Genet. 2014 Jun 1; 23(11): 2858–2879.

https://academic.oup.com/hmg/issue/23/11


Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease.

Andrew O. Koob, Gideon M. Shaked, Andreas Bender, Alejandro Bisquertt, Edward Rockenstein, Eliezer Masliah. Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson’s disease. Brain Res. 2014 Dec 3; 1591: 102–110.

https://www.ncbi.nlm.nih.gov/pubmed/25446004


α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.

Brian Spencer, Changyoun Kim, Tania Gonzalez, Alejandro Bisquertt, Christina Patrick,  Edward Rockenstein, Anthony Adame  Seung-Jae Lee, Paula Desplats, Eliezer Masliah. α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease. Human Molecular Genetics, Volume 25, Issue 6, 15 March 2016, Pages 1100–1115,

https://academic.oup.com/hmg/article/25/6/1100/2384631


A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies.

Edward Rockenstein, Cassia R. Overk, Kiren Ubhi, Michael Mante, Christina Patrick, Anthony Adame, Alejandro Bisquertt, Margarita Trejo-Morales, Brian Spencer, Eliezer Masliah. A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies. PLoS One. 2015; 10(3): e0121570.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121570


Reduction of Blood Amyloid-β Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition.

Lisbell Estrada, David Chamorro, María José Yañez, Marcela Gonzalez, Nancy Leal, Rommy von Bernhardi, Andrés Dulce, Juan Marugan, Marc Ferrer, Claudio Soto, Silvana Zanlungo, Nibaldo Inestrosa, Alejandra Alvarez. Reduction of Blood Amyloid-β Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition. J Alzheimers Dis. 2016 Oct 4;54(3):1193-1205.

https://www.ncbi.nlm.nih.gov/pubmed/27567806


c-Abl stabilizes HDAC2 levels by tyrosine phosphorylation repressing neuronal gene expression in Alzheimer's disease.


Marcelo Gonzalez-Zuñiga, Pablo S. Contreras, Lisbell D. Estrada, David Chamorro, Alejandro Villagra, Silvana Zanlungo, Edward Seto Alejandra R. Alvarez. c-Abl stabilizes HDAC2 levels by tyrosine phosphorylation repressing neuronal gene expression in Alzheimer's disease. Mol Cell. 2014 Oct 2;56(1):163-73.

https://www.ncbi.nlm.nih.gov/pubmed/25219501


Vitamin E dietary supplementation improves neurological symptoms and decreases c-Abl/p73 activation in Niemann-Pick C mice.

Tamara Marín, Pablo Contreras, Juan Francisco Castro, David Chamorro, Elisa Balboa, Mònica Bosch-Morató, Francisco J. Muñoz, Alejandra R. Alvarez,2, and Silvana Zanlungo.Vitamin E dietary supplementation improves neurological symptoms and decreases c-Abl/p73 activation in Niemann-Pick C mice. Nutrients. 2014 Aug; 6(8): 3000–3017

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145291/